aSynPep is a complementary tool to aSynPEP-DB for screening candidate peptides with potentital to bind and inhibit the aggregation of alpha-synuclein.

Back to aSynPEP-DB

If you find this method useful please cite:

1.- Pintado-Grima C, Bárcenas O, Iglesias V, Santos J, Manglano-Artuñedo Z, Pallarès I, Burdukiewicz M, Ventura S. aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation. Database, 2023.

2.- Santos, J., Gracia, P., Navarro, S. et al. α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity. Nat Commun 12, 3752 (2021).

3.- Santos, J., Pallarès, I. and Ventura, S. Is a cure for Parkinson’s disease hiding inside us?. Trends in Biochemical Sciences. (2022).

Additional resources

4.- Muñoz, V. & Serrano, L. Elucidating the folding problem of helical peptides using empirical parameters. Nature: Struct. Biol. 1, 399-409 (1994).

5.- Gautier, R., Douguet, D., Antonny, B. et al. HELIQUEST: a web server to screen sequences with specific α-helical properties. Bioinformatics 24, 18, 2101-2102 (2008).